TY - JOUR AU - Peixoto, Tiago da Cunha AU - de Lima, Eliene Barbosa AU - Farias, Soraya Santos AU - Ferreira, Margareth Moura AU - Macêdo, Alan G.C. AU - Nakazato, Luciano AU - Pescador, Caroline Argenta AU - Mariana Sequeira d’Avila, Mariana Sequeira AU - Carvalho, Vivian Assunção Nogueira AU - Madureira, Karina Medici PY - 2018/05/20 Y2 - 2024/03/29 TI - Outbreaks of conidiobolomycosis caused by Conidiobolus lamprauges in sheep in the state of Bahia, northeastern of Brazil JF - Brazilian Journal of Veterinary Medicine JA - Braz. J. Vet. Med. VL - 39 IS - 4 SE - DO - 10.29374/2527-2179.bjvm018017 UR - https://bjvm.org.br/BJVM/article/view/947 SP - 252-263 AB - <p>The present work describes the occurrence of two conidiobolomycosis outbreaks in Santa Ines breed<br>sheep, in the state of Bahia. The first outbreak (FO) occurred in a property located in Santo Estevao city,<br>involving three animals, and the second outbreak (SO) occurred in a property in Entre Rios city, affecting one&nbsp;</p><p>sheep. In both outbreaks, the clinical findings were characterized by progressive weight loss, dyspnea, and<br>bloody serous nasal discharge. In the FO was also observed unilateral craniofacial asymmetry, associated<br>with exophthalmia and epiphora of the right eye. Autopsies performed on the three FO sheep showed<br>a large mass predominantly yellowish-white with red-black areas of the uneven surface, finely granular,<br>moist and crumbly located in the ethmoidal region, invading the nasopharyngeal, choana, sinuses, retro<br>bulbar region, who infiltrated the cribriform plate and reached the meninges. In two sheep of the FO, the<br>mass reached the front portion of the brain. In SO sheep it was found, on the mucous membrane of the<br>nasal vestibule, small red-black multifocal to coalescing nodules, with eroded surface and hyperemia<br>of the nasal turbinates with hemorrhagic catarrhal secretion, and in the most rostral portion of nasal<br>cavity, the mucosa had a irregular, wet, bleeding and red-black surface, with blackish gray and brownish<br>areas, displaying partial focal destruction of nasal turbinates. Microscopic examination of granulomatous<br>lesions revealed multiple areas of coagulation necrosis containing intense reaction of Splendore-Hoeppli<br>associated with negative images of fungal hyphae and granulomatous inflammation. In all cases, the<br>GMS and PAS staining showed numerous wide hyphae, with bulbous distension at one end. By PCR<br>technique it was characterized Conidiobolus lamprauges by analysis of serum samples of two sheep and<br>paraffin block lesions of one sheep. Immunohistochemical analyzes were positive for C. lamprauges in<br>all animals. It can be proved, for the first time, the occurrence of nasopharyngeal / rhinocerebral and<br>rhinofacial conidiobolomycosis infection by C. lamprauges in the state of Bahia.</p> ER -